PKC-Dependent Phosphorylation of eNOS at T495 Regulates eNOS Coupling and Endothelial Barrier Function in Response to G(+) -Toxins

Gram positive (G(+)) infections make up ∼50% of all acute lung injury cases which are characterized by extensive permeability edema secondary to disruption of endothelial cell (EC) barrier integrity. A primary cause of increased permeability are cholesterol-dependent cytolysins (CDCs) of G(+)-bacter...

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Autori principali: Chen, Feng, Kumar, Sanjiv, Yu, Yanfang, Aggarwal, Saurabh, Gross, Christine, Wang, Yusi, Chakraborty, Trinad, Verin, Alexander D., Catravas, John D., Lucas, Rudolf, Black, Stephen M., Fulton, David J. R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096401/
https://ncbi.nlm.nih.gov/pubmed/25020117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099823
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