Whole Exome Sequencing of Distant Relatives in Multiplex Families Implicates Rare Variants in Candidate Genes for Oral Clefts

A dozen genes/regions have been confirmed as genetic risk factors for oral clefts in human association and linkage studies, and animal models argue even more genes may be involved. Genomic sequencing studies should identify specific causal variants and may reveal additional genes as influencing risk...

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Hlavní autoři: Bureau, Alexandre, Parker, Margaret M., Ruczinski, Ingo, Taub, Margaret A., Marazita, Mary L., Murray, Jeffrey C., Mangold, Elisabeth, Noethen, Markus M., Ludwig, Kirsten U., Hetmanski, Jacqueline B., Bailey-Wilson, Joan E., Cropp, Cheryl D., Li, Qing, Szymczak, Silke, Albacha-Hejazi, Hasan, Alqosayer, Khalid, Field, L. Leigh, Wu-Chou, Yah-Huei, Doheny, Kimberly F., Ling, Hua, Scott, Alan F., Beaty, Terri H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2014
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Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096358/
https://ncbi.nlm.nih.gov/pubmed/24793288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.165225
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