Whole Exome Sequencing of Distant Relatives in Multiplex Families Implicates Rare Variants in Candidate Genes for Oral Clefts

A dozen genes/regions have been confirmed as genetic risk factors for oral clefts in human association and linkage studies, and animal models argue even more genes may be involved. Genomic sequencing studies should identify specific causal variants and may reveal additional genes as influencing risk...

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Main Authors: Bureau, Alexandre, Parker, Margaret M., Ruczinski, Ingo, Taub, Margaret A., Marazita, Mary L., Murray, Jeffrey C., Mangold, Elisabeth, Noethen, Markus M., Ludwig, Kirsten U., Hetmanski, Jacqueline B., Bailey-Wilson, Joan E., Cropp, Cheryl D., Li, Qing, Szymczak, Silke, Albacha-Hejazi, Hasan, Alqosayer, Khalid, Field, L. Leigh, Wu-Chou, Yah-Huei, Doheny, Kimberly F., Ling, Hua, Scott, Alan F., Beaty, Terri H.
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2014
Teme:
Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096358/
https://ncbi.nlm.nih.gov/pubmed/24793288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.165225
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