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Ab Initio Path-Integral Calculations of Kinetic and Equilibrium Isotope Effects on Base-Catalyzed RNA Transphosphorylation Models

Detailed understandings of the reaction mechanisms of RNA catalysis in various environments can have profound importance for many applications, ranging from the design of new biotechnologies to the unraveling of the evolutionary origin of life. An integral step in the nucleolytic RNA catalysis is se...

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Autors principals: Wong, Kin-Yiu, Yuqing, Xu, York, Darrin M.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096342/
https://ncbi.nlm.nih.gov/pubmed/24841935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.23628
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