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Genetic transfer of a nonpeptide antagonist binding site to a previously unresponsive angiotensin receptor.

Mutational analysis based on the pharmacological differences between mammalian and amphibian angiotensin II receptors (AT receptors) previously identified 7 aa residues located in transmembrane domains (TMs) III (Val-108), IV (Ala-163), V (Pro-192, Thr-198), VI (Ser-252), and VII (Leu-300, Phe-301)...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Ji, H, Zheng, W, Zhang, Y, Catt, K J, Sandberg, K
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40960/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7568109/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.20.9240
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