Modulation of Dendritic Cell Immunobiology via Inhibition of 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) Reductase

The maturation status of dendritic cells determines whether interacting T cells are activated or if they become tolerant. Previously we could induce T cell tolerance by applying a 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitor (HMGCRI) atorvastatin, which also modulates MHC class II ex...

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Hauptverfasser: Leuenberger, Tina, Pfueller, Caspar F., Luessi, Felix, Bendix, Ivo, Paterka, Magdalena, Prozorovski, Timour, Treue, Denise, Luenstedt, Sarah, Herz, Josephine, Siffrin, Volker, Infante-Duarte, Carmen, Zipp, Frauke, Waiczies, Sonia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094470/
https://ncbi.nlm.nih.gov/pubmed/25013913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100871
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