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Quickly Finding Orthologs as Reciprocal Best Hits with BLAT, LAST, and UBLAST: How Much Do We Miss?

Reciprocal Best Hits (RBH) are a common proxy for orthology in comparative genomics. Essentially, a RBH is found when the proteins encoded by two genes, each in a different genome, find each other as the best scoring match in the other genome. NCBI's BLAST is the software most usually used for...

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Autors principals: Ward, Natalie, Moreno-Hagelsieb, Gabriel
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094424/
https://ncbi.nlm.nih.gov/pubmed/25013894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101850
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