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Discovery of a Negative Allosteric Modulator of GABA(B) Receptors
[Image: see text] Initialized from the scaffold of CGP7930, an allosteric agonist of GABA(B) receptors, a series of noncompetitive antagonists were discovered. Among these compounds, compounds 3, 6, and 14 decreased agonist GABA-induced maximal effect of IP3 production in HEK293 cells overexpressing...
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| Auteurs principaux: | , , , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Chemical
Society
2014
|
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4094264/ https://ncbi.nlm.nih.gov/pubmed/25050158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500162z |
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