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Carbonic Anhydrase Inhibitors: Design, Synthesis, and Biological Evaluation of Novel Sulfonyl Semicarbazide Derivatives

[Image: see text] A series of novel sulfonyl semicarbazides 5–13 was designed, synthesized, and evaluated for human carbonic anhydrase (hCA) inhibition. The new sulfonyl semicarbazides were tested against a panel of hCA isoforms I, II, IX, and XII, using acetazolamide (AZA, 1) as standard. All the s...

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Autors principals: Pichake, Jayashree, Kharkar, Prashant S., Ceruso, Mariangela, Supuran, Claudiu T., Toraskar, Mrunmayee P.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094246/
https://ncbi.nlm.nih.gov/pubmed/25050167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500140t
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