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N-Glycosylation Is Required for Matriptase-2 Autoactivation and Ectodomain Shedding
Matriptase-2 is a hepatic membrane serine protease that regulates iron homeostasis. Defects in matriptase-2 cause iron deficiency anemia. In cells, matriptase-2 is synthesized as a zymogen. To date, how matriptase-2 expression and activation are regulated remains poorly understood. Here we expressed...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4094060/ https://ncbi.nlm.nih.gov/pubmed/24867957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.555110 |
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