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Human disposition, metabolism and excretion of etamicastat, a reversible, peripherally selective dopamine β-hydroxylase inhibitor

AIMS: Etamicastat is a reversible dopamine-β-hydroxylase inhibitor that decreases noradrenaline levels in sympathetically innervated tissues and slows down sympathetic nervous system drive. In this study, the disposition, metabolism and excretion of etamicastat were evaluated following [(14)C]-etami...

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Detalhes bibliográficos
Main Authors: Loureiro, Ana I, Rocha, Jose F, Fernandes-Lopes, Carlos, Nunes, Teresa, Wright, Lyndon C, Almeida, Luis, Soares-da-Silva, Patricio
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093927/
https://ncbi.nlm.nih.gov/pubmed/24168152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12274
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