Human Metapneumovirus SH and G Glycoproteins Inhibit Macropinocytosis-Mediated Entry into Human Dendritic Cells and Reduce CD4(+) T Cell Activation

Human metapneumovirus (HMPV) is a major etiologic agent of respiratory disease worldwide. HMPV reinfections are common in healthy adults and children, suggesting that the protective immune response to HMPV is incomplete and short-lived. We used gene-deletion viruses to evaluate the role of the attac...

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Bibliographische Detailangaben
Hauptverfasser: Le Nouën, Cyril, Hillyer, Philippa, Brock, Linda G., Winter, Christine C., Rabin, Ronald L., Collins, Peter L., Buchholz, Ursula J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093882/
https://ncbi.nlm.nih.gov/pubmed/24672038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03261-13
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