Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30–60% but no common genetic contribution has be...

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Main Authors: Bolton, Jennifer L., Hayward, Caroline, Direk, Nese, Lewis, John G., Hammond, Geoffrey L., Hill, Lesley A., Anderson, Anna, Huffman, Jennifer, Wilson, James F., Campbell, Harry, Rudan, Igor, Wright, Alan, Hastie, Nicholas, Wild, Sarah H., Velders, Fleur P., Hofman, Albert, Uitterlinden, Andre G., Lahti, Jari, Räikkönen, Katri, Kajantie, Eero, Widen, Elisabeth, Palotie, Aarno, Eriksson, Johan G., Kaakinen, Marika, Järvelin, Marjo-Riitta, Timpson, Nicholas J., Davey Smith, George, Ring, Susan M., Evans, David M., St Pourcain, Beate, Tanaka, Toshiko, Milaneschi, Yuri, Bandinelli, Stefania, Ferrucci, Luigi, van der Harst, Pim, Rosmalen, Judith G. M., Bakker, Stephen J. L., Verweij, Niek, Dullaart, Robin P. F., Mahajan, Anubha, Lindgren, Cecilia M., Morris, Andrew, Lind, Lars, Ingelsson, Erik, Anderson, Laura N., Pennell, Craig E., Lye, Stephen J., Matthews, Stephen G., Eriksson, Joel, Mellstrom, Dan, Ohlsson, Claes, Price, Jackie F., Strachan, Mark W. J., Reynolds, Rebecca M., Tiemeier, Henning, Walker, Brian R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091794/
https://ncbi.nlm.nih.gov/pubmed/25010111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004474
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