Activation of the Unfolded Protein Response Bypasses Trastuzumab-mediated Inhibition of the PI-3K Pathway

HER2-positive breast cancer initially responds to trastuzumab treatment, but over time, resistance develops and rapid cancer progression occurs, for which various explanations have been proposed. Here we tested the hypothesis that induction of the unfolded protein response (UPR) could override HER2...

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Bibliographic Details
Main Authors: Kumandan, Sreekanth, Mahadevan, Navin R., Chiu, Kevin, DeLaney, Alexandra, Zanetti, Maurizio
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091625/
https://ncbi.nlm.nih.gov/pubmed/23200669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2012.11.014
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