PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib

BACKGROUND: Human epidermal growth factor receptor 2 (HER2) is the most crucial ErbB receptor tyrosine kinase (RTK) family member in HER2-positive (refered to HER2-overexpressing) breast cancer which are dependent on or "addictive" to the Phosphatidylinositol-3-kinase (PI3K) pathway. HER2-...

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Autores principales: Wang, Leiping, Zhang, Qunling, Zhang, Jian, Sun, Si, Guo, Haiyi, Jia, Zhen, Wang, Biyun, Shao, Zhimin, Wang, Zhonghua, Hu, Xichun
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141770/
https://ncbi.nlm.nih.gov/pubmed/21676217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-248
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