Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells

Hexokinase II (HKII), a key enzyme of glycolysis, is widely over-expressed in cancer cells. 3-bromopyruvate (3-BrPA), an inhibitor of HK II, has been proposed as a specific antitumor agent. Autophagy is a process that regulates the balance between protein synthesis and protein degradation. Autophagy...

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Autors principals: Zhang, Qianwen, Zhang, Yuanyuan, Zhang, Pei, Chao, Zhenhua, Xia, Fei, Jiang, Chenchen, Zhang, Xudong, Jiang, Zhiwen, Liu, Hao
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
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Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091531/
https://ncbi.nlm.nih.gov/pubmed/25053988
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