Autophagy side of MB21D1/cGAS DNA sensor

The MB21D1/cGAS (Mab-21 domain-containing 1/cyclic GMP-AMP [cGAMP] synthetase), acts as an intracellular pattern recognition receptor (PPR) to sense cytosolic pathogen DNAs and subsequently generates the second messenger cGAMP to initiate the TMEM173/STING pathway for interferon (IFN) production. In...

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Autores principales: Liang, Qiming, Seo, Gil Ju, Choi, Youn Jung, Ge, Jianning, Rodgers, Mary A, Shi, Mude, Jung, Jae U
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2014
Materias:
Autophagic Punctum
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091176/
https://ncbi.nlm.nih.gov/pubmed/24879161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.28769
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