DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells

DIRAS3 is an imprinted tumor suppressor gene that is downregulated in 60% of human ovarian cancers. Re-expression of DIRAS3 at physiological levels inhibits proliferation, decreases motility, induces autophagy, and regulates tumor dormancy. Functional inhibition of autophagy with choroquine in dorma...

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Hlavní autoři: Lu, Zhen, Baquero, Maria T, Yang, Hailing, Yang, Maojie, Reger, Albert S, Kim, Choel, Levine, Douglas A, Clarke, Charlotte H, Liao, Warren S-L, Bast Jr, Robert C
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2014
Témata:
Basic Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091169/
https://ncbi.nlm.nih.gov/pubmed/24879154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.28577
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