Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction

U373MG cells constitutively express glutathione S-transferase mu 2 (GSTM2) and exhibit (3)H-dopamine uptake, which is inhibited by 2 µM of nomifensine and 15 µM of estradiol. We generated a stable cell line (U373MGsiGST6) expressing an siRNA against GSTM2 that resulted in low GSTM2 expression (26% o...

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Detalles Bibliográficos
Autores principales: Huenchuguala, Sandro, Muñoz, Patricia, Zavala, Patricio, Villa, Mónica, Cuevas, Carlos, Ahumada, Ulises, Graumann, Rebecca, Nore, Beston F, Couve, Eduardo, Mannervik, Bengt, Paris, Irmgard, Segura-Aguilar, Juan
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2014
Materias:
Basic Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091149/
https://ncbi.nlm.nih.gov/pubmed/24434817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.27720
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