Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes

Hepatitis C virus (HCV) replication is dependent on the formation of specialized membrane structures; however, the host factor requirements for the formation of these HCV complexes remain unclear. Herein, we demonstrate that inhibition of stearoyl-CoA desaturase 1 (SCD-1) halts the biosynthesis of u...

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Detalhes bibliográficos
Main Authors: Lyn, Rodney K., Singaravelu, Ragunath, Kargman, Stacia, O'Hara, Shifawn, Chan, Helen, Oballa, Renata, Huang, Zheng, Jones, Daniel M., Ridsdale, Andrew, Russell, Rodney S., Partridge, Anthony W., Pezacki, John Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091094/
https://ncbi.nlm.nih.gov/pubmed/25008545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04549
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