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Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors
A positive correlation between stearoyl-CoA desaturase (SCD)1 expression and metabolic diseases has been reported in rodents and humans. These findings indicate that SCD1 is a promising therapeutic target for the chronic treatment of diabetes and dyslipidemia. The SCD1 enzyme is expressed at high le...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137014/ https://ncbi.nlm.nih.gov/pubmed/21642745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M013177 |
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