Evaluation of Apoptosis Induction by Concomitant Inhibition of MEK, mTOR, and Bcl-2 in Human Acute Myeloid Leukemia Cells

Aberrant activation of multiple signaling pathways is common in acute myeloid leukemia (AML) cells, which can be linked to a poor prognosis for patients with this disease. Previous research with mTOR or MEK inhibitors revealed cytostatic, rather than cytotoxic, effects in in vitro and in vivo AML mo...

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Main Authors: Zhang, Weiguo, Ruvolo, Vivian R., Gao, Chen, Zhou, Liran, Bornmann, William, Tsao, Twee, Schober, Wendy D., Smith, Paul, Guichard, Sylvie, Konopleva, Marina, Andreeff, Michael
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090272/
https://ncbi.nlm.nih.gov/pubmed/24739393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0576
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