Metronomic docetaxel in PRINT(®) nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer

The purpose of this study was to investigate the antitumor effects of a combination of metronomic doses of a novel delivery vehicle, PLGA-PRINT nanoparticles containing docetaxel, and anti-angiogenic mEZH2 siRNA incorporated into chitosan nanoparticles. In vivo dose-finding studies and therapeutic e...

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Detalhes bibliográficos
Main Authors: Gharpure, Kshipra M., Chu, Kevin S., Bowerman, Charles, Miyake, Takahito, Pradeep, Sunila, Mangala, Selanere L., Han, Hee-Dong, Rupaimoole, Rajesha, Armaiz-Pena, Guillermo N., Rahhal, Tojan B., Wu, Sherry Y., Luft, J. Christopher, Napier, Mary E, Lopez-Berestein, Gabriel, DeSimone, Joseph M, Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090269/
https://ncbi.nlm.nih.gov/pubmed/24755199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0930
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