Pharmacogenetics of tacrolimus: ready for clinical translation?

Tacrolimus (Tac) exhibits an interindividual pharmacokinetic variability that affects the dose required to reach the target concentration in blood. Tac is metabolized by two enzymes of the cytochrome P450 family, CYP3A5 and CYP3A4. The effect of the CYP3A5 genotype on Tac bioavailability has been de...

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Bibliografiske detaljer
Main Authors: Coto, Eliecer, Tavira, Beatriz, Suárez-Álvarez, Beatriz, López-Larrea, Carlos, Díaz-Corte, Carmen, Ortega, Francisco, Álvarez, Victoria
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Meeting Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089617/
https://ncbi.nlm.nih.gov/pubmed/25028625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/kisup.2011.14
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