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Pharmacogenetics of tacrolimus: ready for clinical translation?

Tacrolimus (Tac) exhibits an interindividual pharmacokinetic variability that affects the dose required to reach the target concentration in blood. Tac is metabolized by two enzymes of the cytochrome P450 family, CYP3A5 and CYP3A4. The effect of the CYP3A5 genotype on Tac bioavailability has been de...

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Detalhes bibliográficos
Main Authors: Coto, Eliecer, Tavira, Beatriz, Suárez-Álvarez, Beatriz, López-Larrea, Carlos, Díaz-Corte, Carmen, Ortega, Francisco, Álvarez, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089617/
https://ncbi.nlm.nih.gov/pubmed/25028625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/kisup.2011.14
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