Pharmacogenetics of tacrolimus: ready for clinical translation?

Tacrolimus (Tac) exhibits an interindividual pharmacokinetic variability that affects the dose required to reach the target concentration in blood. Tac is metabolized by two enzymes of the cytochrome P450 family, CYP3A5 and CYP3A4. The effect of the CYP3A5 genotype on Tac bioavailability has been de...

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Detaylı Bibliyografya
Asıl Yazarlar: Coto, Eliecer, Tavira, Beatriz, Suárez-Álvarez, Beatriz, López-Larrea, Carlos, Díaz-Corte, Carmen, Ortega, Francisco, Álvarez, Victoria
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2011
Konular:
Meeting Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089617/
https://ncbi.nlm.nih.gov/pubmed/25028625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/kisup.2011.14
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