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T-cell co-stimulatory blockade in kidney transplantation: back to the bench

It is believed that blocking positive T-cell co-stimulatory pathways should lead to long-term graft acceptance. Despite the exciting initial achievements in experimental animal models, targeting co-stimulatory pathways has shown to be much more complex in the clinic. In addition to multiple binding...

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Detalhes bibliográficos
Main Authors: Riella, Leonardo V, Sayegh, Mohamed H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089598/
https://ncbi.nlm.nih.gov/pubmed/25018899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/kisup.2011.8
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