Ultra-low Dose Interleukin-2 Promotes Immune-modulating Function of Regulatory T Cells and Natural Killer Cells in Healthy Volunteers

Low-dose interleukin-2 (IL-2) expands regulatory T cells (T(regs)) and natural killer (NK) cells after stem cell transplantation (SCT) and may reduce graft-versus-host disease (GVHD). We hypothesized that ultra-low dose (ULD) IL-2 could serve as an immune-modulating agent for stem cell donors to pre...

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Detalhes bibliográficos
Main Authors: Ito, Sawa, Bollard, Catherine M, Carlsten, Mattias, Melenhorst, Jan Joseph, Biancotto, Angélique, Wang, Ena, Chen, Jinguo, Kotliarov, Yuri, Cheung, Foo, Xie, Zhi, Marincola, Francesco, Tanimoto, Kazushi, Battiwalla, Minoo, Olnes, Matthew J, Perl, Shira, Schum, Paula, Hughes, Thomas E, Keyvanfar, Keyvan, Hensel, Nancy, Muranski, Pawel, Young, Neal S, Barrett, A John
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4089007/
https://ncbi.nlm.nih.gov/pubmed/24686272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.50
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