Soluble Adenylyl Cyclase Is Necessary and Sufficient to Overcome the Block of Axonal Growth by Myelin-Associated Factors

Neurons in the CNS do not regenerate following injury; regeneration is blocked by inhibitory proteins in myelin, such as myelin-associated glycoprotein (MAG). Elevating neuronal levels of the second messenger cAMP overcomes this blocked axonal outgrowth. One way to elevate cAMP is pretreating neuron...

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Bibliographic Details
Main Authors: Martinez, Jennifer, Stessin, Alexander M., Campana, Aline, Hou, Jianwei, Nikulina, Elena, Buck, Jochen, Levin, Lonny R., Filbin, Marie T.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4087207/
https://ncbi.nlm.nih.gov/pubmed/25009261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1434-14.2014
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