Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro

AIM: Skewed cytoplasmic accumulation of NPM mutant protein (NPM1c+) is close related to leukemia pathogenesis. The aim of this study was to investigate whether oridonin, a diterpenoid isolated from the Chinese traditional medicine Rabdosia rubescens, was able to interfere with NPM1c+ protein traffic...

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Autors principals: Li, Fei-fei, Yi, Sha, Wen, Lu, He, Jing, Yang, Li-jing, Zhao, Jie, Zhang, Ben-ping, Cui, Guo-hui, Chen, Yan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086383/
https://ncbi.nlm.nih.gov/pubmed/24902788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.25
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