Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics

Immune responses to some monoclonal antibodies (mAbs) and biologic proteins interfere with their efficacy due to the development of anti-drug antibodies (ADA). In the case of mAbs, most ADA target ‘foreign’ sequences present in the complementarity determining regions (CDRs). Humanization of the mAb...

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Dades bibliogràfiques
Autors principals: De Groot, Anne S, Terry, Frances, Cousens, Leslie, Martin, William
Format: Artigo
Idioma:Inglês
Publicat: Informa Healthcare 2013
Matèries:
Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086238/
https://ncbi.nlm.nih.gov/pubmed/24164613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1586/17512433.2013.835698
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