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Complement C4 maintains peripheral B-cell tolerance in a myeloid cell-dependent manner

The factors that allow self-reactive B cells to escape negative selection and become activated remain poorly defined. Using a B-cell receptor-knock-in mouse strain, we identify a pathway by which B-cell selection to nucleolar self-antigens is complement-dependent. Deficiency in complement component...

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Detalhes bibliográficos
Main Authors: Chatterjee, Priyadarshini, Agyemang, Amma F., Alimzhanov, Marat B., Degn, Soren, Tsiftsoglou, Stefanos A., Alicot, Elisabeth, Jones, Sarah A., Ma, Minghe, Carroll, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086186/
https://ncbi.nlm.nih.gov/pubmed/23749435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343412
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