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Requirement for complement in antibody responses is not explained by the classic pathway activator IgM

Animals lacking complement factors C1q, C2, C3, or C4 have severely impaired Ab responses, suggesting a major role for the classic pathway. The classic pathway is primarily initiated by antigen–Ab complexes. Therefore, its role for primary Ab responses seems paradoxical because only low amounts of s...

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Bibliografische gegevens
Hoofdauteurs: Rutemark, Christian, Alicot, Elisabeth, Bergman, Anna, Ma, Minghe, Getahun, Andrew, Ellmerich, Stephan, Carroll, Michael C., Heyman, Birgitta
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203774/
https://ncbi.nlm.nih.gov/pubmed/21987785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109831108
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