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Requirement for complement in antibody responses is not explained by the classic pathway activator IgM
Animals lacking complement factors C1q, C2, C3, or C4 have severely impaired Ab responses, suggesting a major role for the classic pathway. The classic pathway is primarily initiated by antigen–Ab complexes. Therefore, its role for primary Ab responses seems paradoxical because only low amounts of s...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3203774/ https://ncbi.nlm.nih.gov/pubmed/21987785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109831108 |
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