CMT-associated mutations in glycyl- and tyrosyl-tRNA synthetases exhibit similar pattern of toxicity and share common genetic modifiers in Drosophila

Aminoacyl-tRNA synthetases are ubiquitously expressed proteins that charge tRNAs with their cognate amino acids. By ensuring the fidelity of protein synthesis, these enzymes are essential for viability of every cell. Yet, mutations in six tRNA synthetases specifically affect the peripheral nerves an...

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Detalhes bibliográficos
Main Authors: Ermanoska, Biljana, Motley, William W., Leitão-Gonçalves, Ricardo, Asselbergh, Bob, Lee, LaTasha H., De Rijk, Peter, Sleegers, Kristel, Ooms, Tinne, Godenschwege, Tanja A., Timmerman, Vincent, Fischbeck, Kenneth H., Jordanova, Albena
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086162/
https://ncbi.nlm.nih.gov/pubmed/24807208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.04.020
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