Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy

Charcot-Marie-Tooth disease (CMT) is a length-dependent peripheral neuropathy. The aminoacyl-tRNA synthetases constitute the largest protein family implicated in CMT. Aminoacyl-tRNA synthetases are predominantly cytoplasmic, but are also present in the nucleus. Here we show that a nuclear function o...

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Vydáno v:Nat Commun
Hlavní autoři: Bervoets, Sven, Wei, Na, Erfurth, Maria-Luise, Yusein-Myashkova, Shazie, Ermanoska, Biljana, Mateiu, Ligia, Asselbergh, Bob, Blocquel, David, Kakad, Priyanka, Penserga, Tyrone, Thomas, Florian P, Guergueltcheva, Velina, Tournev, Ivailo, Godenschwege, Tanja, Jordanova, Albena, Yang, Xiang-Lei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834567/
https://ncbi.nlm.nih.gov/pubmed/31695036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12909-9
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