Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1

Cyclic nucleotide-modulated ion channels are important for signal transduction and pacemaking in eukaryotes. The molecular determinants of ligand gating in these channels are still unknown, mainly because of a lack of direct structural information. Here we report ligand-induced conformational change...

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Main Authors: Kowal, Julia, Chami, Mohamed, Baumgartner, Paul, Arheit, Marcel, Chiu, Po-Lin, Rangl, Martina, Scheuring, Simon, Schröder, Gunnar F., Nimigean, Crina M., Stahlberg, Henning
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086158/
https://ncbi.nlm.nih.gov/pubmed/24469021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4106
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