Adenoviral cardiotrophin-1 gene transfer protects pmn mice from progressive motor neuronopathy

Cardiotrophin-1 (CT-1), an IL-6–related cytokine, causes hypertrophy of cardiac myocytes and has pleiotropic effects on various other cell types, including motoneurons. Here, we analyzed systemic CT-1 effects in progressive motor neuronopathy (pmn) mice that suffer from progressive motoneuronal dege...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Bordet, Thierry, Schmalbruch, Henning, Pettmann, Brigitte, Hagege, Albert, Castelnau-Ptakhine, Laetitia, Kahn, Axel, Haase, Georg
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1999
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Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408570/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10525046/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI6265
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