E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia

Acute lung injury (ALI) is linked to mitochondrial injury, resulting in impaired cellular oxygen utilization; however, it is unknown how these events are linked on the molecular level. Cardiolipin, a mitochondrial-specific lipid, is generated by cardiolipin synthase (CLS1). Here, we show that S. aur...

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Main Authors: Chen, Bill B., Coon, Tiffany A., Glasser, Jennifer R., Zou, Chunbin, Ellis, Bryon, Das, Tuhin, McKelvey, Alison C., Rajbhandari, Shristi, Lear, Travis, Kamga, Christelle, Shiva, Sruti, Li, Chenjian, Pilewski, Joseph M., Callio, Jason, Chu, Charleen T., Ray, Anuradha, Ray, Prabir, Tyurina, Yulia Y., Kagan, Valerian E., Mallampalli, Rama K.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085683/
https://ncbi.nlm.nih.gov/pubmed/24703837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.02.048
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