Targeted Resequencing and Systematic In Vivo Functional Testing Identifies Rare Variants in MEIS1 as Significant Contributors to Restless Legs Syndrome

Restless legs syndrome (RLS) is a common neurologic condition characterized by nocturnal dysesthesias and an urge to move, affecting the legs. RLS is a complex trait, for which genome-wide association studies (GWASs) have identified common susceptibility alleles of modest (OR 1.2–1.7) risk at six ge...

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Auteurs principaux: Schulte, Eva C., Kousi, Maria, Tan, Perciliz L., Tilch, Erik, Knauf, Franziska, Lichtner, Peter, Trenkwalder, Claudia, Högl, Birgit, Frauscher, Birgit, Berger, Klaus, Fietze, Ingo, Hornyak, Magdolna, Oertel, Wolfgang H., Bachmann, Cornelius G., Zimprich, Alexander, Peters, Annette, Gieger, Christian, Meitinger, Thomas, Müller-Myhsok, Bertram, Katsanis, Nicholas, Winkelmann, Juliane
Format: Artigo
Langue:Inglês
Publié: Elsevier 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085638/
https://ncbi.nlm.nih.gov/pubmed/24995868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2014.06.005
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