Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis.
The transcription factor GATA-1 recognizes a consensus motif present in regulatory regions of numerous erythroid-expressed genes. Mouse embryonic stem cells lacking GATA-1 cannot form mature red blood cells in vivo. In vitro differentiation of GATA-1- embryonic stem cells gives rise to a population...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1995
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40854/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7568185/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.21.9623 |
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