Functional Characterization of Friedreich Ataxia iPS-Derived Neuronal Progenitors and Their Integration in the Adult Brain

Friedreich ataxia (FRDA) is an autosomal recessive disease characterised by neurodegeneration and cardiomyopathy that is caused by an insufficiency of the mitochondrial protein, frataxin. Our previous studies described the generation of FRDA induced pluripotent stem cell lines (FA3 and FA4 iPS) that...

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Detalhes bibliográficos
Main Authors: Bird, Matthew J., Needham, Karina, Frazier, Ann E., van Rooijen, Jorien, Leung, Jessie, Hough, Shelley, Denham, Mark, Thornton, Matthew E., Parish, Clare L., Nayagam, Bryony A., Pera, Martin, Thorburn, David R., Thompson, Lachlan H., Dottori, Mirella
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084949/
https://ncbi.nlm.nih.gov/pubmed/25000412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101718
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