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A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators
Glucokinase is a glucose-phosphorylating enzyme that regulates insulin release and hepatic metabolism, and its loss-of-function is implicated in the pathogenesis of diabetes. Glucokinase activators (GKAs) are attractive therapeutics in diabetes, however, clinical data indicate that their benefits ca...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4084830/ https://ncbi.nlm.nih.gov/pubmed/24317490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2717 |
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