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A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators

Glucokinase is a glucose-phosphorylating enzyme that regulates insulin release and hepatic metabolism, and its loss-of-function is implicated in the pathogenesis of diabetes. Glucokinase activators (GKAs) are attractive therapeutics in diabetes, however, clinical data indicate that their benefits ca...

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Detalhes bibliográficos
Main Authors: Szlyk, Benjamin, Braun, Craig R., Ljubicic, Sanda, Patton, Elaura, Bird, Gregory H., Osundiji, Mayowa A., Matschinsky, Franz M., Walensky, Loren D., Danial, Nika N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084830/
https://ncbi.nlm.nih.gov/pubmed/24317490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2717
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