DNA immunization to prevent autoimmune diabetes

Mice expressing lymphocytic choriomeningitis virus nucleoprotein (LCMV-NP) as a transgene in their β cells develop insulin-dependent diabetes mellitus (IDDM) only after LCMV infection. Inoculation of plasmid DNA encoding the insulin B chain reduced the incidence of IDDM by 50% in this model. The ins...

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Detaylı Bibliyografya
Asıl Yazarlar: Coon, Bryan, An, Ling-Ling, Whitton, J. Lindsay, von Herrath, Matthias G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 1999
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC408480/
https://ncbi.nlm.nih.gov/pubmed/10411548
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