Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by ex Vivo Granulocyte-Macrophage Colony-stimulating Factor Gene Transfer()

Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-transduced, irradiated tumor vaccines induce potent, T-cell-mediated antitumor immune responses in preclinical models. We report the initial results of a Phase I trial evaluating this strategy for safety and the induction of immune respo...

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Autores principales: Simons, Jonathan W., Jaffee, Elizabeth M., Weber, Christine E., Levitsky, Hyam I., Nelson, William G., Carducci, Michael A., Lazenby, Audrey J., Cohen, Lawrence K., Finn, Christy C., Clift, Shirley M., Hauda, Karen M., Beck, Lisa A., Leiferman, Kristen M., Owens, Albert H., Piantadosi, Steven, Dranoff, Glenn, Mulligan, Richard C., Pardoll, Drew M., Marshall, Fray F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 1997
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084516/
https://ncbi.nlm.nih.gov/pubmed/9108457
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