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Normal levels of the antiprion proteins Btn2 and Cur1 cure most newly formed [URE3] prion variants

[URE3] is an amyloid prion of the Saccharomyces cerevisiae Ure2p, a regulator of nitrogen catabolism. Overproduction of Btn2p, involved in late endosome to Golgi protein transport, or its paralog Cur1p, cures [URE3]. Btn2p, in curing, is colocalized with Ure2p in a single locus, suggesting sequestra...

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Détails bibliographiques
Auteurs principaux: Wickner, Reed B., Bezsonov, Evgeny, Bateman, David A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084489/
https://ncbi.nlm.nih.gov/pubmed/24938787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409582111
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