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Curing of the [URE3] prion by Btn2p, a Batten disease-related protein

[URE3] is a prion (infectious protein), a self-propagating amyloid form of Ure2p, a regulator of yeast nitrogen catabolism. We find that overproduction of Btn2p, or its homologue Ypr158 (Cur1p), cures [URE3]. Btn2p is reported to be associated with late endosomes and to affect sorting of several pro...

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Detalhes bibliográficos
Main Authors: Kryndushkin, Dmitry S, Shewmaker, Frank, Wickner, Reed B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572181/
https://ncbi.nlm.nih.gov/pubmed/18833194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.198
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