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The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading

Excess dietary salt intake induces the activity of the kidney arachidonate epoxygenase and markedly increases the urinary excretion of its metabolites. The epoxyeicosatrienoic acids, products of the kidney P-450 arachidonate epoxygenase, inhibit distal nephron Na(+) reabsorption. Nucleic acid hybrid...

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Auteurs principaux: Holla, Vijaykumar R., Makita, Keiko, Zaphiropoulos, Peter G., Capdevila, Jorge H.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1999
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC408434/
https://ncbi.nlm.nih.gov/pubmed/10491410
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