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Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53

Ischemia and reperfusion activate cardiac myocyte apoptosis, which may be an important feature in the progression of ischemic heart disease. The relative contributions of ischemia and reperfusion to apoptotic signal transduction have not been established. We report here that severe chronic hypoxia a...

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Autori principali: Bishopric, Nanette H., Discher, Daryl J., Kaiser, Shari, Hernandez, Olga, Sato, Barbara, Zang, Jie, Webster, Keith A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC408414/
https://ncbi.nlm.nih.gov/pubmed/10430605
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