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Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53

Ischemia and reperfusion activate cardiac myocyte apoptosis, which may be an important feature in the progression of ischemic heart disease. The relative contributions of ischemia and reperfusion to apoptotic signal transduction have not been established. We report here that severe chronic hypoxia a...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Bishopric, Nanette H., Discher, Daryl J., Kaiser, Shari, Hernandez, Olga, Sato, Barbara, Zang, Jie, Webster, Keith A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 1999
Ämnen:
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408414/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10430605/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI5871
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