Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension

Prostacyclin synthase (PGIS) is the final committed enzyme in the metabolic pathway leading to prostacyclin (PGI(2)) production. Patients with severe pulmonary hypertension have a PGIS deficiency of their precapillary vessels, but the importance of this deficiency for lung vascular remodeling remain...

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Autors principals: Geraci, Mark W., Gao, Bifeng, Shepherd, David C., Moore, Mark D., Westcott, Jay Y., Fagan, Karen A., Alger, Lori A., Tuder, Rubin M., Voelkel, Norbert F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1999
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC408370/
https://ncbi.nlm.nih.gov/pubmed/10359560
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