Mild spherocytosis and altered red cell ion transport in protein 4.2–null mice

Protein 4.2 is a major component of the red blood cell (RBC) membrane skeleton. We used targeted mutagenesis in embryonic stem (ES) cells to elucidate protein 4.2 functions in vivo. Protein 4.2–null (4.2(–/–)) mice have mild hereditary spherocytosis (HS). Scanning electron microscopy and ektacytomet...

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Main Authors: Peters, Luanne L., Jindel, Hitesh K., Gwynn, Babette, Korsgren, Cathy, John, Kathryn M., Lux, Samuel E., Mohandas, Narla, Cohen, Carl M., Cho, Michael R., Golan, David E., Brugnara, Carlo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC408368/
https://ncbi.nlm.nih.gov/pubmed/10359562
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